منابع مشابه
Protein S-palmitoylation in cellular differentiation
Reversible protein S-palmitoylation confers spatiotemporal control of protein function by modulating protein stability, trafficking and activity, as well as protein-protein and membrane-protein associations. Enabled by technological advances, global studies revealed S-palmitoylation to be an important and pervasive posttranslational modification in eukaryotes with the potential to coordinate di...
متن کاملProtein palmitoylation by a family of DHHC protein S-acyltransferases.
Protein palmitoylation refers to the posttranslational addition of a 16 carbon fatty acid to the side chain of cysteine, forming a thioester linkage. This acyl modification is readily reversible, providing a potential regulatory mechanism to mediate protein-membrane interactions and subcellular trafficking of proteins. The mechanism that underlies the transfer of palmitate or other long-chain f...
متن کاملEmerging roles for protein S-palmitoylation in Toxoplasma biology.
Post-translational modifications are refined, rapidly responsive and powerful ways to modulate protein function. Among post-translational modifications, acylation is now emerging as a widespread modification exploited by eukaryotes, bacteria and viruses to control biological processes. Protein palmitoylation involves the attachment of palmitic acid, also known as hexadecanoic acid, to cysteine ...
متن کاملProtein palmitoylation in protozoan parasites.
Palmitoylation plays an important role in the regulation of the localization and function of the modified protein. Although many aspects of protein palmitoylation have been identified in mammalian and yeast cells, little information is available of this modification in protozoan parasites. Protein palmitoylation has been described for a few set of proteins in E.tenella, P. falciparum, T. gondii...
متن کاملProtein palmitoylation in membrane trafficking
Introduction Protein palmitoylation was first described more than 20 years ago for the myelin proteolipid protein, but the functional significance of this post-translational modification remains obscure. Progress has been hampered by the lack of specific inhibitors for acylation and because of the difficulty of developing an assay to isolate the palmitoylating enzyme(s). Palmitoylation generall...
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ژورنال
عنوان ژورنال: Open Biology
سال: 2021
ISSN: 2046-2441
DOI: 10.1098/rsob.200411